Preparation of enteric-coated microspheres of Mycoplasma hyopneumoniae vaccine with cellulose acetate phthalate: The effect of swine serum on micromeritic properties |
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| Authors: | Y. L. Tzan S. Y. Lin C. N. Weng C. J. Lee |
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| Affiliation: | (1) Department of Chemical Engineering, National Tsing Hua University, Hsin-Chu, Taiwan;(2) Department of Medical Research, Veterans General Hospital-Taipei, Taipei, Taiwan;(3) Department of Pathology, Pig Research Institute, Chu-Nan, Taiwan |
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| Abstract: | Summary Cellulose acetate phthalate was used to prepare the Mycoplasma hyopneumoniae vaccine (MHV) microspheres using a solvent evaporation method. Swine serum was used as an additive in the antigen to form the core materials. The addition of serum had a significant effect on surface topography of the MHV microspheres. By using this modified solvent evaporation method, the recoveries of antigens in the MHV microspheres were generally over 90% of the weight and antigenicity of antigens originally added in the formulation. |
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