Fluorescence microscopy applied to intracellular transport by microtubule motors |
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Authors: | Divya Pathak Shreyasi Thakur Roop Mallik |
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Institution: | 1.Department of Biological Sciences,Tata Institute of Fundamental Research,Mumbai,India;2.Department of Physiology,University of Pennsylvania,Philadelphia,USA |
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Abstract: | Long-distance transport of many organelles inside eukaryotic cells is driven by the dynein and kinesin motors on microtubule filaments. More than 30 years since the discovery of these motors, unanswered questions include motor–organelle selectivity, structural determinants of processivity, collective behaviour of motors and track selection within the complex cytoskeletal architecture, to name a few. Fluorescence microscopy has been invaluable in addressing some of these questions. Here we present a review of some efforts to understand these sub-microscopic machines using fluorescence. |
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