Enzymatic synthesis of water-soluble derivatives of salicylic acid in organic media |
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| Authors: | Thierry Maugard Melanie Boulonne Barbara Rejasse Marie Dominique Legoy |
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| Institution: | (1) Laboratoire de Génie Protéique et Cellulaire, EA3169, Université de La Rochelle, Avenue Michel Crépeau, 17042 La Rochelle cedex 1, France |
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| Abstract: | A novel enzymatic method for preparing water-soluble derivatives of salicylic acid catalyzed by immobilized lipase was described. This study is the first to describe the enzymatic transesterification of methyl salicylate in organic solvents with different hydroxyl donors. The acyl-transfer between methyl salicylate and sorbitol was best supported by solvents of log P values –0.33 to 1.4. With Candida antarctica lipase in tert-amyl alcohol, a sorbitol conversion yield of 98% can be obtained by transesterification with sorbitol and methyl salicylate in one step. |
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| Keywords: | Candida antarctica lipase non-conventional media salicylic acid transesterification |
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