Gamma-aminobutyric acid, bicuculline, and post-synaptic binding sites |
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Authors: | E J Peck J M Schaeffer J H Clark |
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Institution: | Department of Biological Sciences Purdue University Lafayette, Indiana 47907 USA |
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Abstract: | The binding of γ-aminobutyric acid (GABA) to synaptosomal fractions of the rat cerebellar cortex has been examined at 0–4°C in the presence and absence of bicuculline, chlorpromazine, and/or Na+. A GABA-binding component has been demonstrated in the synaptosomal fraction which is competitively inhibited by bicuculline. In addition, this binding component persists in the absence of Na+ and in the presence of chlorpromazine. It seems likely that this binding component is the post-synaptic binding site or “receptor” of GABA. |
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