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Potent and selective bicyclic lactam inhibitors of thrombin: Part 3: P1' modifications |
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| Authors: | Plummer J S Berryman K A Cai C Cody W L DiMaio J Doherty A M Eaton S Edmunds J J Holland D R Lafleur D Levesque S Narasimhan L S Rubin J R Rapundalo S T Siddiqui M A Susser A St-Denis Y Winocour P |
| Affiliation: | Parke-Davis Pharmaceutical Research, Division of Warner-Lambert Company, Ann Arbor, MI 48105, USA. |
| Abstract: | The synthesis and antithrombotic activity of a series of nonpeptide bicyclic thrombin inhibitors are described. We have explored the SAR around the P1' site. Modification of the P1' site has been found to affect potency and selectivity. |
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