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Synthesis of bisquinolines and their in vitro ability to produce methemoglobin in canine hemolysate
Authors:Srivastava S  Tewari S  Chauhan P M  Puri S K  Bhaduri A P  Pandey V C
Institution:Division of Biochemistry, Central Drug Research Institute, Lucknow, India.
Abstract:Synthesis of a number of derivatives of bisquinolines (3-9) have been reported here. Effect of these compounds on in vitro methemoglobin formation and methemoglobin reductase activity has resulted in the identification of two potential compounds (5 & 7), showing negligible methemoglobin toxicity.
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