Synthesis of bisquinolines and their in vitro ability to produce methemoglobin in canine hemolysate |
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Authors: | Srivastava S Tewari S Chauhan P M Puri S K Bhaduri A P Pandey V C |
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Institution: | Division of Biochemistry, Central Drug Research Institute, Lucknow, India. |
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Abstract: | Synthesis of a number of derivatives of bisquinolines (3-9) have been reported here. Effect of these compounds on in vitro methemoglobin formation and methemoglobin reductase activity has resulted in the identification of two potential compounds (5 & 7), showing negligible methemoglobin toxicity. |
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