| NADPH氧化酶与ROS信号区域化 |
| |
| 引用本文： | 陈丽云),张正红),),王正朝). NADPH氧化酶与ROS信号区域化[J]. 中国生物化学与分子生物学报, 2014, 30(2): 137-143 |
| |
| 作者姓名： | 陈丽云) 张正红) ) 王正朝) |
| |
| 作者单位： | 1）福建师范大学生命科学学院 福建省发育与神经生物学重点实验室, 福州350007; 2 )扬州大学兽医学院 江苏省转基因制药工程研究中心, 江苏 扬州225009 |
| |
| 基金项目： | 国家自然科学基金（No..31101032, No.31271255）, 教育部新世纪优秀人才支持计划(No.NCET 120614), 教育部博士点基金(No.20113503120002)和福建省高校杰出青年基金项目(No.AJ11041) |
| |
| 摘 要： | 最近有关活性氧物质 (ROS)的研究取得了突飞猛进的进展，尤其是其作为第二信使介导了许多生理性与病理性细胞事件,包括细胞分化、过度生长、增殖及凋亡.为了避免ROS的毒性产生特异性的信号转导,ROS的产生与代谢必须被严格调控；其具体的调控机制一直是人们关注的焦点. 最近有关ROS区域化观点的提出解决了这一问题. NADPH是生成ROS的主要来源. 研究发现，NADPH氧化酶及其衍生的ROS存在于机体的多种组织内,且在细胞中呈区域化分布,对细胞内信号的精确调控具有至关重要的作用. NADPH一方面通过小窝/脂筏组装成功能型复合物,从而产生ROS区域化；另一方面,NADPH通过其不同亚细胞定位亚基与各种靶蛋白之间的相互作用,产生ROS特异性. 本文系统综述了NADPH衍生的ROS信号区域化,为进一步理解ROS信号在各种生理或病理过程的分子调控机制提供理论依据.
|
| 关 键 词： | NADPH氧化酶 活性氧物质 (ROS) 区域化 |
| 收稿时间： | 2013-06-13 |
NADPH Oxidase and ROS Signaling Compartmentalization |
| |
| CHEN Li-Yun ）,ZHANG Zheng-Hong ）,),WANG Zheng-Chao ). NADPH Oxidase and ROS Signaling Compartmentalization[J]. Chinese Journal of Biochemistry and Molecular Biology, 2014, 30(2): 137-143 |
| |
| Authors: | CHEN Li-Yun ） ZHANG Zheng-Hong ） ) WANG Zheng-Chao ) |
| |
| Affiliation: | 1）Key Laboratory for Developmental Biology and Neurosciences of Province, College of Life Sciences, Fujian Normal University, Fuzhou350007, China; 2) Research Center for Animal Transgenesis and Biopharming of Jiangsu, College of Veterinary Medicine, Yangzhou University, Yangzhou225009,Jiangsu, China |
| |
| Abstract: | Functioning as a second messenger, reactive oxygen species (ROS) mediates various cellular events in physiological or pathological conditions, including cell differentiation, excessive growth, proliferation and apoptosis. The generation and metabolism of ROS is strictly regulated through specific signaling systems in cells to avoid cytotoxicity. The research concerning the involved regulatory mechanism has recently focused on the ROS localization and compartmentalization. NADPH oxidase produces ROS in many tissures at certain compartments of cells, forms functional complex, and plays a crucial role in the precise control of intracellular signals. The NADPH oxidase subunit interactions with certain target proteins may define specific subcellular localization of ROS. This review describes the ROS signal compartmentalization from NADPH oxidase and may improve the current understanding on molecular mechanism of ROS. |
| |
| Keywords: | NADPH oxidase reactive oxygen species (ROS) compartmentalization |
| 本文献已被 CNKI 等数据库收录！ |
| 点击此处可从《中国生物化学与分子生物学报》浏览原始摘要信息 |
|
点击此处可从《中国生物化学与分子生物学报》下载全文 |
|
