| 胎球蛋白A/AHSG的结构与生物学功能 |
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| 引用本文： | 陈婷,毕捷,曹诚. 胎球蛋白A/AHSG的结构与生物学功能[J]. 中国生物化学与分子生物学报, 2014, 30(7): 636-641. DOI: 10.13865/j.cnki.cjbmb.2014.07.003 |
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| 作者姓名： | 陈婷 毕捷 曹诚 |
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| 作者单位： | (军事医学科学院卫生勤务与医学情报研究所，北京100850;军事医学科学院生物工程研究所，北京100071;内蒙古科技大学, 内蒙古 包头014010) |
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| 基金项目： | 国家重点基础研究发展规划（973计划,No. 2012CB518900) 资助 |
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| 摘 要： | 胎球蛋白A(fetuin-A/ AHSG)是一种由肝脏分泌的人血浆糖蛋白．它在人体血液中的含量与外伤感染、心血管疾病、结石、SARS等疾病相关．AHSG具有高度的遗传多态性，其基因的多态性位点与Ⅱ型糖尿病、血管钙化和SARS的易感性等相关．AHSG有多种生物学功能：能够抑制碱性磷酸钙（basic calcium phosphate, BCP）沉淀，维持体液中钙含量；能够参与巨噬细胞失活，调控炎症程度；能够抑制胰岛素受体自身磷酸化和其酪氨酸激酶的活性，导致产生胰岛素抵抗和Ⅱ型糖尿病；能够与转化生长因子-β（transforming growth factor, TGF-β）结合，进而抑制肠肿瘤的生长．本文将近年来关于AHSG的结构、遗传多态性、含量和生物学功能的研究进展情况作一概述．
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| 关 键 词： | 胎球蛋白(fetuin-A/AHSG) 胰岛素抵抗 炎症 肿瘤 |
| 收稿时间： | 2013-10-25 |
Structure and Biological Functions of Fetuin-A/α2-HS Glycoprotein |
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| CHEN Ting,BI Jie,CAO Cheng. Structure and Biological Functions of Fetuin-A/α2-HS Glycoprotein[J]. Chinese Journal of Biochemistry and Molecular Biology, 2014, 30(7): 636-641. DOI: 10.13865/j.cnki.cjbmb.2014.07.003 |
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| Authors: | CHEN Ting BI Jie CAO Cheng |
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| Affiliation: | (Institute of Health Service and Medical Information, Academy of Military Medical Sciences, Beijing100850, China; Institute of Biotechnology, Academy of Military Medical Sciences, Beijing100071, China;Inner Mongolia University of Science & Technology, Baotou014010, Inner Mongolia, China) |
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| Abstract: | The fetuin-A(also known as α2-Heremans-Schmid glycoprotein, AHSG) is a trauma-related plasma glycoprotein secreted by the liver. AHSG polymorphism appeared to be associated with the susceptivity of type II diabetic, vessel calcification and SARS. AHSG functions include preventing basic calcium phosphate(BCP) from precipitation to maintain blood calcium level; to inactivate macrophages to suppress inflammation; to extend insulin receptor phosphorylation and PTK activity that contribute to insulin resistance and type II diabetes. AHSG also binds to TGF-β to attenuate the growth of intestinal tumors. This review discusses recent discoveries about fetuin-A/AHSG of its structure, genetic polymorphism, and biological functions. |
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| Keywords: | fetuin-A/&alpha 2-HS glycoprotein insulin resistance inflammationt umor |
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