Ischemic flow threshold for striatal dopamine release in rats |
| |
Authors: | Hiroshi Yao Hiroaki Ooboshi Seizo Sadoshima Kentaro Takano Setsuro Ibayashi Masatoshi Fujishima |
| |
Institution: | (1) Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Maidashi 3-1-1, 812 Fukuoka, Japan |
| |
Abstract: | To determine the level of cerebral blood flow reduction which causes striatal dopamine release, extracellular dopamine and cerebral blood flow was simultaneously determined using in vivo brain dialysis and a hydrogen clearance method, respectively, in the striatum of spontaneously hypertensive rats, before and during experimental cerebral ischemia. The ischemic flow threshold for neurotransmitter dopamine release was found to be 20% of the resting value or 8–10 ml/100g/min of cerebral blood flow, being similar to those for energy and membrane failures. |
| |
Keywords: | Cerebral ischemia dopamine release flow threshold in vivo brain dialysis striatum spontaneously hypertensive rats |
本文献已被 SpringerLink 等数据库收录! |
|