Unsaturated phosphatidylcholines inhibit superoxide production in human neutrophils. |
| |
Authors: | K Yoshida V Mohsenin |
| |
Affiliation: | John B. Pierce Laboratory, Yale University School of Medicine, New Haven, Connecticut 06519. |
| |
Abstract: | Unsaturated long chain phosphatidylcholines such as phosphatidylcholine dioleoyl and phosphatidylcholine dilinoleoyl in micromolar concentrations inhibited the superoxide production in neutrophils stimulated by the activators of protein kinase C, phorbol 12-myristate 13-acetate and 1,2-dioctanoyl-sn- glycerol. In contrast, the superoxide production induced by surface receptor agonist, formyl-methionyl-leucyl-phenylalanine, was unaffected by the phospholipids. These data suggest that surfactant phosphatidylcholines may have a modulatory role on neutrophil oxidative burst in the lung during inflammation where there is a preponderance of unsaturated phosphatidylcholines. |
| |
Keywords: | |
|
|