Calcium-activated calcium permeability in parathyroid cells |
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| Authors: | E Gylfe R Larsson H Johansson P Nygren J Rastad C Wallfelt G Akerstr?m |
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| Institution: | 1. Department of Medical Cell Biology, University of Uppsala, BMC Box 571, S-751 23 Uppsala, Sweden;2. Department of Surgery, University Hospital, S-751 85 Uppsala, Sweden |
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| Abstract: | The Ca2+ receptor mechanism of the parathyroid cell was studied using La3+ as a probe. La3+ was found to bind to the cell surface without further penetration. Measurements of 45Ca fluxes and the cytoplasmic Ca2+ concentration (Ca2+i) revealed a stimulatory component in the action of La3+ on Ca2+ permeability resulting in a rise in Ca2+i. These effects mimicked those obtained when raising the extracellular Ca2+ concentration from 0.5 to 3.0 mM, but the actions of La3+ and Ca2+ were not additive. The results suggest the existence of a novel Ca2+ permeability physiologically activated by binding of Ca2+ to an external receptor. |
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