A dilatometric study of the denaturation of bovine serum albumin by guanidine hydrochloride |
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| Authors: | S Lapanje J Skerjanc |
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| Affiliation: | Department of Chemistry, University of Ljubljana, Yugoslavia |
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| Abstract: | The denaturation of bovine serum albumin by guanidine hydrochloride was studied using the dilatometric method. From dilatometric measurements the differences between the partial specific volume of the protein in denaturant solutions and water, respectively, were determined. The differences reflect the extent of unfolding as well as the binding of the denaturant. From the differences and the known partial specific volume of the native protein, the partial specific volumes at individual denaturant concentrations were obtained. |
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