Ipsilateral vagotomy to unilaterally ovariectomized pre-pubertal rats modifies compensatory ovarian responses |
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Authors: | Leticia Morales Beatriz Ricardo Adán Bolaños Roberto Chavira Roberto Domínguez |
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Institution: | 1. Biology of Reproduction Research Unit. Physiology of Reproduction Laboratory FES Zaragoza., UNAM. AP 9-020, CP 15000, México, DF. México 2. Instituto Nacional de Ciencias Médicas y de la Nutrición, Salvador Zubirán, México
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Abstract: | The present study evaluates the participation of the vagus nerve in pre-pubertal rats with unilateral ovariectomy on puberty
onset, and on progesterone, testosterone and estradiol serum levels, and the compensatory responses of the ovary. Unilateral
vagotomy did not modify the onset of puberty in unilaterally ovariectomized rats. Ovulation rates of animals with the left
vagus nerve sectioned and the left ovary in-situ was lower than in rats with only unilateral ovariectomy. Sectioning the left
vagus to 32-day old rats with the left ovary in-situ resulted in lower compensatory ovarian hypertrophy than in rats with
right unilateral ovariectomy. Twenty-eight or 32-day old animals with sectioning of the right vagus nerve and the right ovary
in situ showed higher compensatory ovulation. Twenty-eight -day old rats with the right ovary in situ had higher progesterone
and testosterone levels than animals of the same age with the left ovary in-situ. Compared to animals with the right ovary
in situ, animals treated at 32-days of age, sectioning the ipsi-lateral vagus nerve resulted in higher progesterone levels.
Higher progesterone levels were observed in 28- and 32 days old rats with the left ovary in situ and left vagus nerve sectioned.
Thirty-two day old animals with the right ovary in situ and right vagus nerve sectioned had higher progesterone levels than
rats of the same age with the left ovary in situ and left vagus nerve sectioned. Left vagotomy to 28-day old rats with the
left ovary in situ resulted in higher testosterone levels, a reverse response to that observed in animals with sectioning
of the right vagus and the right ovary in situ. Thirty-two day old rats with the left ovary in situ and left vagus nerve sectioned
showed lower testosterone levels than animals without vagotomy and with the left ovary in situ. |
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