Genistein reverses changes of the proteome induced by oxidized-LDL in EA.hy 926 human endothelial cells |
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| Authors: | Fuchs Dagmar Erhard Petra Turner Rufus Rimbach Gerald Daniel Hannelore Wenzel Uwe |
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| Institution: | Department of Food and Nutrition, Molecular Nutrition Unit, Technical University of Munich, Hochfeldweg 2, D-85350 Freising, Germany. |
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| Abstract: | Endothelial cells are primary targets for pro-atherosclerotic stressors such as oxidized LDL (ox-LDL). The isoflavone genistein, on the other hand, is suggested to prevent a variety of processes underlying atherosclerosis and cardiovascular diseases. By analyzing the proteome of EA.hy 926 endothelial cells, here we show, that genistein reverses the ox-LDL-induced changes of the steady-state levels of several proteins involved in atherosclerosis. These alterations caused by genistein are functionally linked to the inhibition of ox-LDL induced apoptosis. |
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