Piroxicam, a structurally novel anti-inflammatory compound. Mode of prostaglandin synthesis inhibition |
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| Authors: | Thomas J. Carty Joann S. Stevens Joseph G. Lombardino M. John Parry Michael J. Randall |
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| Affiliation: | 1. Central Research, Pfizer Inc. Groton, Connecticut 06340, USA;2. Sandwich, England, UK |
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| Abstract: | Piroxicam is a potent inhibitor of prostaglandin biosynthesis. Experiments utilizing cell culture and microsomes derived from various sources have demonstrated that piroxicam is a selective inhibitor of the cyclooxygenase step of arachidonic acid metabolism. Little blocking activity is observed at the phospholipase, thromboxane or prostacyclin synthetase, and arachidonic acid lipoxygenase steps. |
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