Clathrin adaptors really adapt |
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Authors: | Kirchhausen Tom |
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Institution: | Department of Cell Biology, Harvard Medical School and The Center for Blood Research, Boston, MA 02115, USA. kirchhausen@xta1200.harvard.edu |
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Abstract: | The clathrin pathway is the principal route for receptor-mediated endocytosis and growth factor downregulation. Heterotetrameric clathrin adaptors directly link the clathrin coat with cargo transmembrane proteins that are sorted into coated pits and vesicles. A paper in this issue of Cell describes the atomic structure of the adaptor-protein 2 (AP-2) core, the portion that makes contacts with the membrane and cytosolic tails of cargo proteins. |
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