Interactions between a non-terpenoid carbamate with juvenile hormone activity and esterases in the last larval instar of Adoxophyes reticulana Huebn |
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Authors: | P Masner G Hüsler A Pryde S Dorn |
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Institution: | Dr R. Maag Ltd, CH-8157 Dielsdorf, Switzerland |
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Abstract: | The summer fruit tortrix moth is very susceptible to compounds with juvenile hormone activity. Ro 13-5223, a non-terpenoid carbamate, is 3–4 orders of magnitude more active in inhibiting metamorphosis in the last-instar larvae than juvenile hormone I. Larvae reared in permanent contact with this substance are characterised by higher juvenile hormone esterase activity but lower α-naphthyl esterase activity when compared to the untreated controls. In vitro Ro 13-5223 inhibits juvenile hormone hydrolysis but only in dosages which are far above the concentrations found in haemolymph of larvae exposed to the 14C-labelled compound. It does not serve as a substrate for juvenile hormone esterase in vitro even though it induces the enzyme activity in vivo. All these characteristics may account for the very high biological activity of Ro 13-5223 which disrupts humoral coordination of insect development. |
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