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Hypoglycemic and hepatoprotective activity of Rosmarinus officinalis extract in diabetic rats |
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| Authors: | Kholoud S Ramadan Olfat A Khalil Enas N Danial Hanan S Alnahdi Najla O Ayaz |
| Institution: | 1. Department of Biochemistry, Faculty of Girls Science, King Abdulaziz University, Jeddah, Saudi Arabia 2. Department of Biochemistry, Faculty of Science, Ain Shams University, Cairo, Egypt 3. Clinical Biochemistry Department, Faculty of Medicine, El-Azher University, Cairo, Egypt 4. Chemistry of Natural and Microbial Products Department, National Research Center, El-Behooth Street, Dokki, Cairo, Egypt |
| Abstract: | The present study examined the effect of water extract (200 mg/kg body weight) of Rosmarinus officinalis L. in streptozotocin (STZ)-induced diabetic rats for 21 days. The hepatoprotective effects were investigated in the liver tissues sections. There was a significant increase in serum liver biochemical parameters (aspartate aminotransferase, alanine transaminase, and alkaline phosphatase), accompanied by a significant decrease in the level of total protein and albumin in the STZ-induced rats when compared with that of the normal group. The high-dose treatment group (200 mg/kg body wt) significantly restored the elevated liver function enzymes near to normal. This study revealed that rosemary extracts exerted a hepatoprotective effect. The results indicate that the extract exhibits the protective effect on tissues and prove its potentials as an antidiabetic agent. |
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