注意缺损多动障碍和儿茶酚-O-甲基转移酶基因无关联性

以往研究表明，儿茶酚胺系统可能参于注意缺损多动障碍（attention—deficit hyperactivityity disorder，ADHD）的发生，而儿茶酚胺-O-甲基转移酶（catechel—O—methyltransferase，COMT）是一种降解多巴胺和去甲肾上腺素系统的儿茶酚胺神经递质的酶。因此，采用两种以家系为基础的分析方法，即传递不平衡实验（transmission disequilibrium test，TDT）和单倍型为基础的单倍型相对风险率（haplotype—based haplotype relative risk，HHRR）去探讨COMT和中国人群中79个ADHD核心家系的关联性，ADHD诊断符合DSM—IV的诊断标准。TDT（X^2=1．03，df=1，P〉0．05）和HHRR（X^2=1．08，df=1，P〉0．05）两种方法的分析结果表明，COMT等位基因不能优先传递给ADHD儿童，提示在中国人群中ADHD与COMT基因无关联性。

No Association Between Attention-Deficit Hyperactivity Disorder and CatechoI-O-Methyltransferase Gene in Chinese

Previous studies suggested that the catecholaminergic systems may be involved in the pathogenesis of attention-deficit hyperactivity disorder(ADHD). Since catechei-o-methyltransferase(COMT) is an enzyme involved in the degradation of catecholaminergic neurotransmitters of the dopaminergic and noradrenergic systems,it is possible that COMT may play a role in ADHD. To test this hypothesis,we used two family-based analyses,the transmission disequilibrium test (TDT) and the haplotype-based haplotype relative risk (HHRR), to examine the possible association between COMT gene and DSM-Ⅳ-diagnosed ADHD in a Chinese sample consisting of 79 ADHD probands and their parents. Both TDT (x2 =1.03,df=1 ,P＞0.05) and HHRR (x2 =1.08,df= 1, P ＞0.05) analyses failed to detect preferential transmission of a COMT allele to the ADHD children. Our data suggested that there was no association between ADHD and the COMT gene in the Chinese population.