Facile synthesis of N-(1-alkenyl) derivatives of 2,4-pyrimidinediones |
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Authors: | Henriksen U |
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Affiliation: | Department of Chemistry, University of Copenhagen, H. C. Orsted Institute, Denmark. |
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Abstract: | N-(1-alkenyl) derivatives of 2,4-pyrimidinediones (6-9) were prepared in a one pot synthesis from aldehydes and the nucleobases using trimethylsilyl trifluoromethanesulfonate (TfOTMS) as coupling reagent. Presilylation of the above nucleobases, and N6-benzoyladenine, with excess N,O-bis(trimethylsilyl)acetamide (BSA) followed by addition of one mol eq. TfOTMS yielded the N-(1-trimethylsilyloxyalkyl) derivatives 1-5. |
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