Activation of the human immunodeficiency virus type 1 enhancer is not dependent on NFAT-1. |
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| Authors: | D M Markovitz M C Hannibal M J Smith R Cossman G J Nabel |
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| Affiliation: | Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor 48109-0650. |
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| Abstract: | The function of a putative NFAT-1 site in the human immunodeficiency virus type 1 enhancer has been analyzed. Activation by the T-cell antigen receptor is minimal in Jurkat cells and is mediated by the kappa B sites. The putative NFAT-1 region is not required for the response to anti-CD3 or to mitogens in T-cell, B-cell, or monocyte/macrophage leukemia lines, nor is it a cis-acting negative regulatory element. |
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