Antigen delivery by attenuated Bacillus anthracis: new prospects in veterinary vaccines |
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| Authors: | F Brossier M Mock J -C Sirard |
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| Institution: | Unité Toxines et Pathogénie Bactériennes, Institut Pasteur, Paris, France. |
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| Abstract: | This report summarizes the recent investigations on the use of Bacillus anthracis as a live vector for delivery of antigens. Recombinant strains were constructed by engineering the current live Sterne vaccine. This vaccine, used to prevent anthrax in cattle, causes side-effects due to anthrax toxin activities. Bacteria producing a genetically detoxified toxin factor were devoid of lethal effects and were as protective as the Sterne strain against experimental anthrax. Moreover, B. anthracis expressing a foreign antigen controlled by an in vivo inducible promoter were able to generate either antibody or cellular protective responses against heterologous diseases. |
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