Mangiferin attenuates MPTP induced dopaminergic neurodegeneration and improves motor impairment,redox balance and Bcl-2/Bax expression in experimental Parkinson’s disease mice |
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Authors: | Mani Kavitha Jagatheesan Nataraj Musthafa Mohammed Essa Mushtaq A Memon Thamilarasan Manivasagam |
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Institution: | 1. Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalai Nagar 608 002, Tamilnadu, India;2. Department of Food Science and Nutrition, CAMS, Sultan Qaboos University, Muscat, Oman;3. Ageing and Dementia Research Group, Sultan Qaboos University, Muscat, Oman;4. College of Veterinary Medicine, Washington State University, Pullman, WA, United States |
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Abstract: | Mangiferin, a polyphenol compound of C-glucoside, is well-known for its anti-inflammatory, antioxidant, anticancer, antidiabetic and cognitive enhancement properties. In this study, we investigated the neuroprotective effect of mangiferin against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson’s disease (PD), which is most popular and widely used to evaluate therapeutic implications of new protective agents. Male C57BL/6 mice were orally treated with mangiferin (10, 20 and 40 mg/kg body wt.) for 14 days and from 10th day onwards MPTP (30 mg/kg, i.p.) was injected for last 5 days. MPTP treatment leads to enhanced oxidative stress, induction of apoptosis (upregulates the expression of Bax, proapoptotic protein and downregulates the expression of anti-apoptotic marker Bcl-2), and loss of dopominergic neurons which results in motor impairments. Results of our study confirmed that mangiferin prevented MPTP-induced behavioral deficits, oxidative stress, apoptosis, dopaminergic neuronal degeneration and dopamine depletion. Taken together, we conclude that mangiferin attenuates the dopaminergic neurodegeneration mainly through its potent antioxidant and antiapoptotic properties. |
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Keywords: | Experimental Parkinson&rsquo s disease Mangiferin Behavior Oxidative stress Anti-apoptosis |
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