High-performance liquid chromatographic determination of terguride in solid dosage forms and plasma |
| |
| Authors: | J. Sochor, J. Klime,M. rumov |
| |
| Affiliation: | 1. Department of Oral and Maxillofacial Surgery, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University，56th Lingyuanxi Road, Guangzhou, Guangdong 510055, China;2. Guangdong Province Key Laboratory of Stomatology, No. 74, 2nd Zhongshan Road, Guangzhou 510080, Guangdong, China;1. Universidad de Málaga, Facultad de Ciencias, Departamento de Química Analítica, Campus de Teatinos s/n, 29071 Málaga, Spain;2. ENEA (FSN-TECFIS-DIM), Via E. Fermi 45, Frascati (RM), Italy |
| |
| Abstract: | A simple and rapid HPLC method was developed to determine terguride in terguride hydrogenmaleate, coated tablets and plasma. The assay was carried out on a glass column of SGX CN (150 × 3.3 mm I.D.) using methanol and phosphate buffer solution (pH 7.0) as the mobile phase, with detection at 227 nm. Terguride was quantified using promethazine as an internal standards. The tablet matrix was extracted into methanol. Plasma samples were deproteinated with acetonitrile and the supernatant was injected into the HPLC system. The method is linear, quantitative and reproducible. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
