HLA supratypes in an Italian population |
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| Authors: | Sandra D'Alfonso Nazario Cappello Iolanda Borelli Gina Mazzola Daniela Peruccio Mara Giordano Isabella Cascino Roberto Tosi Patricia Momigliano Richiardi |
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| Institution: | (1) Department of Genetics, Biology, and Medical Chemistry, Torino University, Via Santena 19, 10 126 Torino, Italy;(2) Center for Immunogenetics and Histocompatibility, CNR, Via Santena 19, 10 126 Torino, Italy;(3) Department of Medical Sciences, Torino University, Via Solaroli 17, 28 100 Novora, Italy;(4) Institute of Cell Biology, CNR, Viale Marx 43, 00 137 Rome, Italy |
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| Abstract: | A supratype analysis of a North Italian population was performed, using 16 polymorphisms in the HLA region spanning the HLA-A-DP segment. Fourteen supratypes were identified, mostly corresponding to those found in other Caucasiod populations. The degree of their conservation both within the B-DR/DQ region and in the regions telomeric and centromeric from HLA-A and DP was evaluated and linkage disequilibria among several DR and DP alleles were identified. Notably, the degree of association with DP increased when the DR marker was part of a conserved B-DR/DQ supratype. These data are relevant to the definition of the genetic structure of the population and to the prediction of probabilities of histocompatibility matching between unrelated individuals. |
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