Cross-bridge behavior in rigor muscle |
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Authors: | E F Pate C J Brokaw |
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Institution: | (1) Division of Biology, California Institute of Technology, 91125 Pasadena, CA, USA;(2) Present address: Department of Pure and Applied Mathematics, Washington State University, 99164 Pullman, WA, USA |
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Abstract: | Properties of the rigor state in muscle can be explained by a simple cross-bridge model, of the type which has been suggested for active muscle, in which detachment of cross-bridges by ATP is excluded. Two attached cross-bridge states, with distinct force vs. distortion relationships, are required, in addition to a detached state, but the attached cross-bridge states in rigor muscle appear to differ significantly from the attached cross-bridge states in active muscle. The stability of the rigor force maintained in muscle under isometric conditions does not require exceptional stability of the attached cross-bridges, if the positions in which attachment of cross-bridges is allowed are limited so that the attachment of cross-bridges in positions which have minimum free energy is excluded. This explanation of the stability of the rigor state may also be applicable to the maintenance of stable rigor waves on flagella. |
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Keywords: | Muscle rigor Cross-bridge model Insect fibrillar muscle Cross-bridge stiffness |
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