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New tools and new biology: Recent miniaturized systems for molecular and cellular biology |
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| Authors: | Morgan Hamon Jong Wook Hong |
| Institution: | 1. Materials Research and Education Center, Department of Mechanical Engineering, Auburn University, Auburn, AL, 36849, USA 2. College of Pharmacy, Seoul National University, Seoul, 151-741, Korea 3. Department of Bionano Engineering, Hanyang University, Ansan, 426-791, Korea |
| Abstract: | Recent advances in applied physics and chemistry have led to the development of novel microfluidic systems. Microfluidic systems allow minute amounts of reagents to be processed using μm-scale channels and offer several advantages over conventional analytical devices for use in biological sciences: faster, more accurate and more reproducible analytical performance, reduced cell and reagent consumption, portability, and integration of functional components in a single chip. In this review, we introduce how microfluidics has been applied to biological sciences. We first present an overview of the fabrication of microfluidic systems and describe the distinct technologies available for biological research. We then present examples of microsystems used in biological sciences, focusing on applications in molecular and cellular biology. |
| Keywords: | cellular biology human-on-a-chip microfluidics molecular biology organ-on-a-chip worm-on-a-chip |
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