Base-pairing systems related to TNA containing phosphoramidate linkages: synthesis of building blocks and pairing properties |
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Authors: | Ferencic Mathias Reddy Goverdhan Wu Xiaolin Guntha Sreenivasulu Nandy Jyoti Krishnamurthy Ramanarayanan Eschenmoser Albert |
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Institution: | The Skaggs Institute for Chemical Biology at The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA-92037, USA. |
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Abstract: | As part of a project that aims at screening TNA-related oligonucleotide systems in which threose backbone units may have some or all of their oxygen functions replaced by nitrogen, two TNA analogs containing (2'NH)- and (3'NH)-phosphoramidate groups, respectively, in place of phosphodiester groups were synthesized. They show base-pairing properties that are very similar to those of TNA itself. We also synthesized 2',3'-diamino analogs of alpha-L-threofuranosyl mononucleosides, yet attempts to convert them to TNA analogs containing phosphodiamidate linker groups were not successful. Such 2',3'-diamino derivatives of threofuranosyl nucleosides may be of interest, however, as building blocks of TNA analogs that contain non-phosphorous linker groups. |
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