Antitumor-promoting effects of new sesquiterpenes from Crossopetalum tonduzii |
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| Authors: | Mendoza Cristina R Jiménez Ignacio A Tokuda Harukuni Kushida Hiroyuki Bazzocchi Isabel L |
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| Institution: | Instituto Universitario de Bio-Orgánica Antonio González, Universidad de La Laguna, Avenida Astrofísico Francisco Sánchez 2, La Laguna, 38206 Tenerife. |
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| Abstract: | Seven new sesquiterpenes (1-7) with a 'dihydro-beta-agarofuran' (= 5,11-epoxy-5beta,10alpha-eudesmane) skeleton were isolated from Crossopetalum tonduzii. Their structures were elucidated spectroscopically, especially by means of homo- and heteronuclear NMR correlation (COSY, ROESY, HSQC, and HMBC). The absolute configurations of the new compounds were determined by circular dichroism (CD) studies and by chemical correlations via the derivatives 8-11. The new compounds showed moderate antitumor-promoting effects with respect to the activation of the Epstein-Barr virus early antigen (EBV-EA). |
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