Three new immunomodulating C21-steroidal glycosides from the stems of Stephanotis mucronata |
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Authors: | Li Xiaoyu Sun Hongxiang Ye Yiping Chen Fengyang Tu Jue Pan Yuanjiang |
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Affiliation: | Department of Chemistry, Zhejiang University, Hangzhou 310027, PR China. |
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Abstract: | Three new C(21)-steroidal glycosides stemucronatosides H, I, and J (1-3, resp.) were isolated from the stems of Stephanotis mucronata, together with three known compounds sinomarinoside A (4), sinomarinoside E (5), and stephanoside H (6). These isolated compounds were tested for their immunological activities in vitro against concanavalin-A(Con A)- and lipopolysaccharide(LPS)-induced proliferation of mice splenocytes. Compounds 3, 4, and 6 showed immunosuppressive activities in a dose-dependent manner, while compounds 1, 2, and 5 possessed immunoenhancing activities. |
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