The effect of adenine nucleotides on the rate and fate of glutamine utilization by incubated mitochondria isolated from rat mesenteric lymph nodes |
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| Authors: | Rui Curi Eric A Newsholme |
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| Institution: | (1) Department of Biochemistry, Oxford University, South Parks Road, OX1 3QU, United Kingdom;(2) Department of Physiology and Biophysics, Institute of Biomedical Sciences, São Paulo University, 05508 Butantan, Sao Paulo, SP, Brazil |
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| Abstract: | Summary The rate of glutamine utilization by isolated lymphocyte mitochondria is 21.4 nmol/min per mg protein, of which 72% is converted to glutamate. Addition of ATP, ADP or AMP increased the rate of glutamine utilization by 60%. Evidence is presented that this is due to a stimulation of oxoglutarate dehydrogenase activity by ADP: this may account for the stimulation of glutamine utilization by concanavalin A in lymphocyte. |
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| Keywords: | lymphocytes glutamine mitochondria ADP oxoglutarate dehydrogenase |
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