Expression of the RNA binding proteins,Mel-N1, Mel-N2, and Mel-N3 in adipose cells |
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Authors: | Qi Chen Wheeler James A Pruett Ashlie Pekala Phillip H |
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Institution: | Department of Biochemistry and Molecular Biology, The Brody School of Medicine, East Carolina University, Greenville, NC 27858, USA. |
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Abstract: | Mel-N1 (murine embryonic lethal abnormal vision ELAV]), a mammalian homolog of Drosophila ELAV, is an mRNA binding protein of the RNA Recognition Motif family. Studies with the human homolog, Hel-N1 have supported the hypothesis that Hel-N1, and its splice variant, Hel-N2 play a role in mRNA metabolism. Thus it becomes logical to extend this hypothesis to the murine variant Mel-N1 which has been described as a neuronal protein with a minor level of expression in the testis. Our current work expands the potential function for this protein through demonstration of expression of the full-length message and splice variants in adipose tissue as well as preadipocyte and adipocyte cell lines. |
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Keywords: | Adipocyte 3T3-L1 cells Mel-N1 RNA binding protein Hu proteins ELAV Glucose transporter mRNA stability |
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