Structural insight into the antibiotic action of telithromycin against resistant mutants |
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| Authors: | Berisio Rita Harms Joerg Schluenzen Frank Zarivach Raz Hansen Harly A S Fucini Paola Yonath Ada |
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| Affiliation: | Max-Planck-Research Unit for Ribosomal Structure, Hamburg, Germany. |
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| Abstract: | The crystal structure of the ketolide telithromycin bound to the Deinococcus radiodurans large ribosomal subunit shows that telithromycin blocks the ribosomal exit tunnel and interacts with domains II and V of the 23S RNA. Comparisons to other clinically relevant macrolides provided structural insights into its enhanced activity against macrolide-resistant strains. |
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