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Polysaccharides isolated from <Emphasis Type="Italic">Phellinus baumii</Emphasis> stimulate murine splenocyte proliferation and inhibit the lipopolysaccharide-induced nitric oxide production in RAW264.7 murine macrophages |
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| Authors: | Z Q Chang B C Oh M H Rhee J C Kim S P Lee S C Park |
| Institution: | (1) College of Veterinary Medicine, Kyungpook National University, Daegu, 702-701, Republic of Korea;(2) Microbial Genomics Laboratory, Korea Research Institute of Bioscience and Biotechnology, Daejon, 305-600, Republic of Korea;(3) College of Veterinary Medicine, Chonnam National University, Gwangju, 500-757, Republic of Korea;(4) The Center for Traditional Microorganism Resources, Keimyung University, Daegu, 704-701, Republic of Korea |
| Abstract: | Polysaccharides isolated from Phellinus baumii (PBP) significantly enhanced both lipopolysaccharide (LPS)-induced B lymphocyte proliferation and concanavalin A (Con A)-induced T lymphocyte proliferation. However, PBP (12.5–100 μg ml−1) significantly suppressed the LPS-induced nitric oxide (NO) production in RAW264.7 cells in a concentration-dependent manner. The maximal inhibition of PBP on NO production was 37.5% at 100 μg ml−1. These results provide useful in vitro information to explain the immunostimulating activity and anti-inflammatory activity of PBP. |
| Keywords: | Nitric oxide Phellinus baumii Polysaccharide Splenocyte proliferation |
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