Synthesis,Fungistatic, Protistocidal,and Antibacterial Activity of 1-(3-Amino-2-Hydroxypropyl)Indoles |
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| Authors: | Email author" target="_blank">K?F?SuzdalevEmail author L?D?Popov A?A?Zubenko Yu?D?Drobin L?N?Fetisov A?N?Bodryakov N?M?Serbinovskaya |
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| Institution: | 1.Chemical Department of Southern Federal University,Rostov-on-Don,Russia;2.North-Caucasian Zonal Scientific Research Veterinary Institute,Novocherkassk,Russia |
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| Abstract: | A series of new indole derivatives containing the 3-amino-2-hydroxypropyl group at the nitrogen atom has been synthesized by the ring-opening of the oxirane cycle of 1-oxiranylmethylindoles. Their antibacterial, fungicidal, and protistocidal activities have been studied. Most of the synthesized compounds have been shown to exhibit a high protistocidal activity that several times exceeds that of the reference drug, baikoks (toltrazuril). |
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