Evaluation of antioxidant and antiproliferative metabolites of <Emphasis Type="Italic">Penicillium flavigenum</Emphasis> isolated from hypersaline environment: Tuz (Salt) Lake by Xcelligence technology |
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| Authors: | Email author" target="_blank">Z?CanturkEmail author E?Kocabiyik N?Ozturk S??lhan |
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| Institution: | 1.Pharmacy Faculty, Deparment of Pharmaceutical Microbiology,Anadolu University,Eskisehir,Turkey;2.Institu of Science,Eskisehir Osmangazi University,Eskisehir,Turkey;3.Pharmacy Faculty, Deparment of Pharmacognosy,Anadolu University,Eskisehir,Turkey;4.Faculty of Science and Letters, Departments of Basic and Industrial Microbiology,Eskisehir Osmangazi University,Eskisehir,Turkey |
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| Abstract: | The aim of the study is the determination of antioxidant and antiproliferative activities of fungal isolates’ metabolites belonging to Penicillium flavigenum isolated from Lake Tuz, Turkey. Evaluation of the antioxidant activity, the total phenolic content and antiproliferative effect were evaluated with DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging assay, Folin-ciocalteu method, Xcelligence real-time cell analysis. The total phenolic content of these isolates were found 62–82 mg/GAE. Ethyl acetate extracts from identified isolates, P. flavigenum, showed cytotoxic effects on A549, MCF7, Caco-2 cell lines. IC50 values of P. flavigenum ethyl acetate extracts were found 96.7 μg/mL for A549, 33.4 μg/mL for MCF7, 43.4 μg/mL for Caco-2 and 97.3 μg/mL for 3T3. Phenolic acids in the extracts from P. flavigenum were identified with HPLC and GC-MS. Penicillium flavigenum is a new report for Turkey. According to these findings, fungi-related secondary metabolites are very important sources in terms of antioxidant and antiproliferative effects. |
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