Analysis of the effects of different salt consumption levels on the urine protein composition during a 105-day isolation using the opoSOM program |
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| Authors: | L?H?Pastushkova Email author" target="_blank">D?N?KashirinaEmail author A?G?Brzhozovsky V?A?Ivanisenko E?S?Tiys A?S?Kononikhin N?L?Starodubtseva E?N?Nikolaev H?Binder I?M?Larina |
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| Institution: | 1.Institute of Biomedical Problems,Russian Academy of Sciences,Moscow,Russia;2.Institute of Cytology and Genetics, Siberian Branch,Russian Academy of Sciences,Novosibirsk,Russia;3.Kulakov Research Center for Obstetrics, Gynecology, and Perinatology,Ministry of Health of Russian Federation,Moscow,Russia;4.Moscow Institute of Physics and Technology (State University),Dolgoprudny,Russia;5.Interdisciplinary Center for Bioinformatics,Leipzig University,Leipzig,Germany |
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| Abstract: | The aim of the research was the study of changes in urine protein composition of healthy human under controlled living conditions during 105-day experiment (Mars-500 program) at different salt consumption levels. Modern proteomic methods based on chromatography–mass spectrometry, as well as different techniques of bioinformatics (including the opoSOM program), were used. Three time ranges with different dynamics of the protein detection were isolated: initial (weeks 1–6 of the experiment), intermediate (weeks 7–11), and final (weeks 12–15). About 10 different groups of jointly detectable proteins, directly associated with the periods of different salt consumption level, were identified during the work. In particular, their biological functions, tissue specificity, and signaling pathways, in which these proteins are involved in the human body, were determined. |
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