Age-related adaptive responses of mitochondria of the retinal pigment epithelium to the everyday blue LED lighting |
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| Authors: | Email author" target="_blank">N?B?SerezhnikovaEmail author L?S?Pogodina T?V?Lipina N?N?Trofimova T?S?Gurieva P?P?Zak |
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| Institution: | 1.Emanuel Institute of Biochemical Physics,Russian Academy of Sciences,Moscow,Russia;2.Moscow State University,Moscow,Russia;3.Institute of Medical and Biological Problems,Russian Academy of Sciences,Moscow,Russia |
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| Abstract: | The effect of everyday blue light (λ = 440–460 nm) on mitochondria of the retinal pigment epithelium of different age groups of Japanese quail was studied using electron microscopy, morphometric methods, and biochemical analysis. We have found a significant increase in the number of mitochondria, including those modified, mainly in young birds. In addition, cell metabolic activity increased in response to blue lighting. These changes are assumed to reflect an adaptive response of mitochondria aimed at neutralizing the phototoxic effect of blue light caused by accumulation of lipofuscin granules. |
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