Different effects of the immunostimulatory drug Stimforte on infections of hepatitis C virus and herpes simplex virus type 1 |
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Authors: | Email author" target="_blank">D?G?MaldovEmail author V?L?Andronova S?S?Grigorian E?I?Isaeva P?G?Deryabin D?V?Mishin A?A?Balakina A?V?Ilyichev A?A?Terentyev G?A?Galegov |
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Institution: | 1.ZAO SKY LTD,Moscow,Russia;2.Gamaleya Institute of Epidemiology and Microbiology,Ministry of Health,Moscow,Russia;3.Institute of Problems of Chemical Physics,Russian Academy of Sciences,Chernogolovka,Russia |
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Abstract: | Stimforte, an immune response-stimulating preparation, is active with respect to hepatitis C virus (HCV) and herpes simplex virus type I (HSV-1). The effects of Stimforte in animals infected with either HCV or HSV-1 are fundamentally different. In mice with acute herpes virus infection, Stimforte administration leads to a higher activity of natural killer cells and cytotoxic lymphocytes, and the amount of interferon (IFN) λ grows. In mice infected with HCV, Stimforte administration results in a significant increase in IFN-β but not IFN-λ in blood and affected organs. Stimforte has been found to affect directly HCV reproduction that causes the infected cell death, but it does not affect HSV-1 reproduction in the Vero cells (V). |
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