CHE1 UF serum cholinesterase phenotype in whites and non-whites from southern Brazil as determined by a new method |
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| Authors: | V M Alcantara E A Chautard-Freire-Maia L Culpi |
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| Affiliation: | Department of Genetics, Federal University of Paraná, Curitiba, Brazil. |
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| Abstract: | A sample of 251 Whites and 818 Non-Whites, from Curitiba (southern Brazil), was typed with a new method with the aim of estimating the frequency of the CHE1*F allele. The frequency of this allele did not differ between Whites (0.60 +/- 0.34%) and Non-Whites (0.49 +/- 0.17%), being estimated as 0.51 +/- 0.15% for the whole sample. The use of the inhibitors DL-propranolol and RO2-0683 with alpha-naphthylacetate as substrate (at 37 degrees C) was efficient for discriminating between the CHE1 U and CHE1 UF phenotypes. |
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