The in vitro metabolism of progesterone, 4-androstene-3,17-dione, testosterone and 17 beta-hydroxy-5 alpha-androstan-3-one by fetal rhesus monkey testes. |
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| Authors: | J C Coffey R E Johnsonbaugh |
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| Affiliation: | 1. The Dental Research Center; The Department of Pediatrics, School of Medicine; The Department of Parasitology and Laboratory Practice, School of Public Health; The University of North Carolina Chapel Hill N.C. 27514 U.S.A.;2. The Department of Pediatrics (Endocrine Division) National Naval Medical Center and the Uniformed Services University of the Health Sciences Bethesda, Md. 20014 U.S.A. |
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| Abstract: | Homogenates prepared from fetal rhesus monkey testes were incubated with progesterone, 4-androstene-3,17-dione, testosterone and 17 beta-hydroxy-5 alpha-androstan-3-one. The major progesterone metabolite was 17-hydroxy-4-pregnene-3,20-dione. Testosterone also accumulated in the progesterone incubations. 4-Androstene-3,17-dione was converted chiefly to testosterone. Testosterone was not actively metabolized by the fetal monkey testis. 17 beta-Hydroxy-5 alpha-androstan-3-one was actively converted primarily to 5 alpha-androstane-3 beta,17 beta-diol. |
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