| 肿瘤细胞抗TRAIL凋亡诱导的分子机制 |
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| 引用本文： | 郦萍,吴雪昌.肿瘤细胞抗TRAIL凋亡诱导的分子机制[J].细胞生物学杂志,2006,28(2):153-159. |
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| 作者姓名： | 郦萍 吴雪昌 |
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| 作者单位： | 浙江大学生命科学学院 杭州310012 |
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| 基金项目： | 国家自然科学基金资助项目(No.30100115)~~ |
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| 摘 要： | 肿瘤坏死因子相关的凋亡诱导配体(tumornecrosisfactor-relatedapoptosis-inducingligand,TRAIL)是肿瘤坏死因子(tumornecrosisfactor,TNF)超家族的成员之一,它能选择性诱导肿瘤细胞凋亡,对大多数正常细胞无杀伤作用。研究表明,某些恶性肿瘤抵抗TRAIL诱导的凋亡,且TRAIL重复作用使一些TRAIL敏感的细胞产生获得性抗性,这是TRAIL应用于肿瘤治疗的重大障碍。现对与TRAIL凋亡诱导通路直接相关的抗TRAIL机制及由Akt等途径介导的抗性分子机制进行综述。
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| 关 键 词： | TRAIL 凋亡 抗性机制 Akt途径 |
| 收稿时间： | 2005-07-25 |
| 修稿时间： | 2005-11-25 |
Molecular Mechanisms of Resistance to TRAIL-induced Apoptosis in Tumor |
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| Ping Li,Xue-Chang Wu.Molecular Mechanisms of Resistance to TRAIL-induced Apoptosis in Tumor[J].Chinese Journal of Cell Biology,2006,28(2):153-159. |
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| Authors: | Ping Li Xue-Chang Wu |
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| Institution: | College of Life Sciences, Zhejiang University, Hangzhou 310012, China |
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| Abstract: | Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is one of severalmembers of the TNF gene super-family that selectively induces apoptosis of tumor cells, but not normal cells.However, several recent researches show that numbers of malignant tumors cells are resistant to apoptosis inducedby TRAIL, and repeated application of TRAIL protein to some cancer cells that were originally sensitive to TRAIL-induced apoptosis results in acquired resistance. This review summarized the resistant mechanisms targeted theapoptosis pathway induced by TRAIL, and the molecular mechanisms of resistance mediated by other TRAILactivated pathway, such as Akt pathway. |
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| Keywords: | TRAIL apoptosis resistant mechanism Akt pathway |
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