Complete genetic characterization of a Brazilian dengue virus type 3 strain isolated from a fatal outcome |
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| Authors: | Miagostovich Marize Pereira dos Santos Flávia Barreto Fumian Túlio Machado Guimarães Flávia Ramos da Costa Eliane Veiga Tavares Fernando Neto Coelho Janice Oliveira Nogueira Rita Maria Ribeiro |
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| Institution: | Departamento de Virologia, Instituto Oswaldo Cruz-Fiocruz, Rio de Janeiro, RJ, 21040-900, Brasil. marizepm@ioc.fiocruz.br |
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| Abstract: | We have determined the complete nucleotide and the deduced amino acid sequences of Brazilian dengue virus type 3 (DENV-3) from a dengue case with fatal outcome, which occurred during an epidemic in the state of Rio de Janeiro, Brazil, in 2002. This constitutes the first complete genetic characterization of a Brazilian DENV-3 strain since its introduction into the country in 2001. DENV-3 was responsible for the most severe dengue epidemic in the state, based on the highest number of reported cases and on the severity of clinical manifestations and deaths reported. |
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