Regulatory T cells in rheumatoid arthritis |
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Authors: | Jan?Leipe Alla?Skapenko Peter?E?Lipsky Email author" target="_blank">Hendrik?Schulze-KoopsEmail author |
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Institution: | (1) Nikolaus Fiebiger Center for Molecular Medicine, University of Erlangen-Nuremberg, Erlangen, Germany;(2) National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA; |
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Abstract: | Apart from the deletion of autoreactive T cells in the thymus, various methods exist in the peripheral immune system to control
specific human immune responses to self-antigens. One of these mechanisms involves regulatory T cells, of which CD4+CD25+ T cells are a major subset. Recent evidence suggests that CD4+CD25+ T cells have a role in controlling the development of autoimmune diseases in animals and in humans. The precise delineation
of the function of CD4+CD25+ T cells in autoimmune inflammation is therefore of great importance for the understanding of the pathogenesis of autoimmune
diseases. Moreover, the ability to control such regulatory mechanisms might provide novel therapeutic opportunities in autoimmune
disorders such as rheumatoid arthritis. Here we review existing knowledge of CD4+CD25+ T cells and discuss their role in the pathogenesis of rheumatic diseases. |
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