8-Hydroxyguanosine and 8-methoxyguanosine possess immunostimulating activity for B lymphocytes |
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| Authors: | A Ahmad J J Mond |
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| Institution: | 1. Disease Biology Lab, Department of Biosciences, Sri Sathya Sai Institute of Higher Learning, Vidyagiri, Prasanthi Nilayam, Anantapur 515134, India;2. Sri Sathya Sai General Hospital, Puttaparthi, Anantapur 515134, India;1. The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Nankai University, Tianjin, China;2. School of Chemical Technology, Aalto University, P.O. Box 16100, 00076 Aalto, Finland;3. Tianjin Environmental Protection Technical Development Center, Tianjin, China;1. Natural Food Macromolecule Research Center, School of Food and Biological Engineering, Shaanxi University of Science and Technology, Xi’an 710021, PR China;2. Shaanxi Academy of Traditional Chinese Medicine, Xi''an 710003, China;1. Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023, China;2. Department of Integrated Chinese and Western Medicine, School of Chinese Medicine & School of Integrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023, China;1. Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge CB2 0AW, UK;2. Division of Gastroenterology and Hepatology, Department of Medicine, University of Cambridge, Addenbrooke’s Hospital, Cambridge CB2 0QQ, UK;3. Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK;4. Division of Gastroenterology, Hepatology and Endoscopy, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA;5. Division of Infectious Diseases, Department of Medicine, University of Cambridge, Cambridge CB2 0QQ, UK |
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| Abstract: | The present paper extends previous observations of Goodman and Weigle (M.G. Goodman and W.O. Weigle, J. Immunol. 128, 2399, 1982) and describes the activation of B lymphocytes by a number of C-8-substituted guanine ribonucleosides. 8-Hydroxyguanosine stimulates both proliferation and differentiation of murine B cells while 8-methoxyguanosine stimulates only differentiation and 8-aminoguanosine has no discernible effect on B-cell activation. The former two compounds also increase the magnitude of the antibody response to the type 2 antigen trinitrophenyl-AECM-Ficoll. These data demonstrate that guanosine, which is itself inhibitory to murine B cells, is converted into an immunostimulatory molecule after substitution at its C-8 position with methoxy or hydroxy groups and the bromo or mercapto group not essential for conferring biological activity to this nucleoside. However, our data also suggest that substitution of different groups at the C-8 position does influence the biological activity of this molecule. |
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