Induction of beta-polymerase mRNA by DNA-damaging agents in Chinese hamster ovary cells. |
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| Authors: | A J Fornace Jr B Zmudzka M C Hollander and S H Wilson |
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| Institution: | Radiation Oncology Branch, National Cancer Institute, Bethesda, Maryland 20892. |
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| Abstract: | Only a few of the genes involved in DNA repair in mammalian cells have been isolated, and induction of a DNA repair gene in response to DNA damage has not yet been established. DNA polymerase beta (beta-polymerase) appears to have a synthetic role in DNA repair after certain types of DNA damage. Here we show that the level of beta-polymerase mRNA is increased in CHO cells after treatment with several DNA-damaging agents. |
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