Experimental vaccine strategies for cancer immunotherapy |
| |
| Authors: | Chien-Hung Chen T -C Wu MD PhD |
| |
| Institution: | (1) Department of Internal Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan;(2) Department of Oncology, Johns Hopkins Medical Institutions, Baltimore, Md., USA;(3) Department of Obstetrics and Gynecology, Johns Hopkins Medical Institutions, Baltimore, Md., USA;(4) Department of Molecular Microbiology and Immunology, Johns Hopkins Medical Institutions, Baltimore, Md., USA;(5) Department of Pathology, Johns Hopkins University, 644 Ross Building, 720 Rutland Avenue, 21205 Baltimore, MD, USA |
| |
| Abstract: | Recently, cancer immunotherapy has emerged as a therapeutic option for the management of cancer patients. This is based on the fact that our immune system, once activated, is capable of developing specific immunity against neoplastic but not normal cells. Increasing evidence suggests that cell-mediated immunity, particularly T-cell-mediated immunity, is important for the control of tumor cells. Several experimental vaccine strategies have been developed to enhance cell-mediated immunity against tumors. Some of these tumor vaccines have generated promising results in murine tumor systems. In addition, several phase I/II clinical trials using these vaccine strategies have shown extremely encouraging results in patients. In this review, we will discuss many of these promising cancer vaccine strategies. We will pay particular attention to the strategies employing dendritic cells, the central player for tumor vaccine development. |
| |
| Keywords: | Tumor immunology Cancer Vaccine Immunotherapy Antigen Cytotoxic T lymphocyte Dendritic cell |
| 本文献已被 SpringerLink 等数据库收录！ |
|
