Genetic Control of Phosphate-Metabolizing Enzymes in NEUROSPORA CRASSA: Relationships among Regulatory Mutations |
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| Authors: | Barbara S. Littlewood William Chia Robert L. Metzenberg |
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| Affiliation: | Department of Physiological Chemistry, University of Wisconsin, Madison, Wisconsin 53706 |
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| Abstract: | In Neurospora crassa, the phosphate-metabolizing enzymes are made during phosphate starvation, but not under phosphate sufficiency. The synthesis of these enzymes is controlled by three regulatory genes: pcon-nuc-2, preg and nuc-1, pcon-nuc-2 and preg are closely linked. A model of the hierarchical relationships among these regulatory genes is presented. Studies of double mutants and revertants confirm several predictions of the model. It has been found that nuc-2 (null) and pcon-c (constitutive) mutations reside in the same cistron. preg-c (constitutive) mutations are epistatic to nuc-2 mutations. nuc-1 (null) mutations are epistatic to all others. |
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