Modulations in the biotransformation of tobacco extract and N'-nitrosonornicotine under differential dietary protein status |
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Authors: | N Ammigan U J Nair A J Amonkar S V Bhide |
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Institution: | Cancer Research Institute, Tata Memorial Centre, Parel, Bombay, India. |
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Abstract: | The modulation of the phase I and phase II biotransformation enzymes upon treatment with tobacco extract (TE) and N'-nitrosonornicotine (NNN) was investigated using male Sprague-Dawley rats fed differential protein diets. It was observed that the animals fed a low protein diet showed an overall decrease in the basal levels of hepatic and pulmonary phase I and II enzymes. TE and NNN significantly decreased the detoxifying system in the low-protein-fed animals. Animals fed 20% protein, however, showed significant increases in glutathione and glutathione S-transferase upon treatment. Furthermore, TE and NNN treatment brought about a significant depletion in the hepatic pool of vitamin A with a concomitant increase in the vitamin C levels. |
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