Somatic cell mapping of T-cell receptor CD3 complex and CD8 genes in cattle |
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| Authors: | Lei Li Alan Teale Albert Bensaid Sabrina Dunlap Allan B Dietz James E Womack |
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| Institution: | (1) Department of Veterinary Pathobiology, Texas A&M University, 77843 College Station, TX, USA;(2) International Laboratory for Research on Animal Diseases, P.O. Box 30709, Nairobi, Kenya;(3) Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A&M University, 77843 College Station, Texas, USA |
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| Abstract: | Bovine genes encoding T-cell receptor, CD3, and CD8 molecules have been mapped to syntetic groups using bovine × rodent hybrid somatic cells. T-cell receptor  and  chains were assigned to bovine syntenic group U5, and the  and  genes were syntenic with each other and with markers on U13. CD3E and CD3D genes were syntenic with each other and located to bovine syntenic group U19. CD8 was most concordant with markers of syntenic group U16, although the concordancy was only 85% and the assignment must be regarded as tentative. The comparative gene maps of human chromosome 7, bovine syntenic group U13, and mouse chromosomes 6 and 13 suggest extensive evolutionary conservation. |
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